在突触发生过程中阻断神经节传递会降低鸡睫状神经节和虹膜中α-银环蛇毒素的结合。

Blockade of ganglionic transmission during synaptogenesis decreases alpha-bungarotoxin binding in the chick ciliary ganglion and iris.

作者信息

Chiappinelli V A

出版信息

Brain Res. 1982 Sep;281(1):118-21. doi: 10.1016/0165-3806(82)90121-3.

Abstract

The role of normal synaptic activity in the biochemical development of the nervous system has been examined in the chick embryo. Chlorisondamine, a ganglionic blocking drug, was administered in ovo during the period of synaptogenesis in the parasympathetic ciliary ganglion. Following treatment with chlorisondamine, nicotinic binding sites (as measured with [125I] alpha-bungarotoxin) were significantly reduced in both the ganglion and its end organ, the striated iris muscle. While the number of [125I] alpha-bungarotoxin binding sites eventually approached control levels in the iris, binding in the ciliary ganglion remained below normal values through hatching.

摘要

正常突触活动在神经系统生化发育中的作用已在鸡胚中进行了研究。在副交感神经睫状神经节突触形成期，向鸡胚卵内注射神经节阻断药氯筒箭毒碱。用氯筒箭毒碱处理后，神经节及其终末器官（横纹肌虹膜）中的烟碱结合位点（用[125I]α-银环蛇毒素测定）均显著减少。虽然[125I]α-银环蛇毒素结合位点的数量最终在虹膜中接近对照水平，但睫状神经节中的结合在孵化时仍低于正常值。