κ-银环蛇毒素：一项细胞内研究表明一种蛇神经毒素可阻断神经元烟碱受体

Kappa-bungarotoxin: an intracellular study demonstrating blockade of neuronal nicotinic receptors by a snake neurotoxin.

作者信息

Dryer S E, Chiappinelli V A

出版信息

Brain Res. 1983 Dec 19;289(1-2):317-21. doi: 10.1016/0006-8993(83)90033-1.

Abstract

Pressure injection of carbachol elicited dose-dependent depolarizations of the principal ganglionic neurons in embryonic chick ciliary ganglia. These depolarizations were associated with a marked decrease in input resistance. Carbachol-induced depolarizations were completely and reversibly antagonized by the snake neurotoxin Kappa-bungarotoxin but not by alpha-bungarotoxin. Kappa-bungarotoxin, therefore, appears to be a specific probe for the postsynaptic neuronal nicotinic receptor in the avian ciliary ganglion.

摘要

向鸡胚睫状神经节中注射卡巴胆碱可引起神经节主要神经元出现剂量依赖性的去极化。这些去极化与输入电阻的显著降低有关。卡巴胆碱诱导的去极化可被蛇神经毒素κ-银环蛇毒素完全且可逆地拮抗，但α-银环蛇毒素则不能。因此，κ-银环蛇毒素似乎是鸟类睫状神经节中突触后神经元烟碱受体的特异性探针。