Miller A D, Roossin P S, Schor R H
Exp Brain Res. 1982;48(1):107-12. doi: 10.1007/BF00239577.
The effects of lesions of the vestibulospinal tracts on vestibular reflexes evoked by roll tilt in forelimb and neck extensors were examined in decerebrate cats. Sectioning the medial longitudinal fasciculus, which contains the medial vestibulospinal tract, had no major effect on the phase of the reflex, although some gain was usually lost at high stimulus frequencies. Spinal lesions at C2-C3, both cord hemisections and more restrictive lesions which cut the lateral vestibulospinal tract, produced two major effects on the forelimb. Background EMG activity was usually abolished in the triceps ipsilateral to the lesion, with partial loss of activity in the opposite limb. The tilt reflex response in the ipsilateral limb appeared normal, although it was usually necessary to raise the background excitability of the preparation by administering L-Dopa in order to observe the reflex. In contrast, the response in the contralateral limb showed a phase reversal of 180 deg at low stimulus frequencies, implying that the reflex in intact cats receives a crossed otolith-spinal input. Responses in the neck extensors splenius and biventer, recorded from compartments caudal to the spinal lesion, were relatively unaffected.
在去大脑的猫身上，研究了前庭脊髓束损伤对翻滚倾斜诱发的前肢和颈部伸肌前庭反射的影响。切断包含内侧前庭脊髓束的内侧纵束，对反射的相位没有重大影响，尽管在高刺激频率下通常会损失一些增益。C2 - C3水平的脊髓损伤，包括脊髓半切和更局限的切断外侧前庭脊髓束的损伤，对前肢产生了两个主要影响。损伤同侧肱三头肌的背景肌电图活动通常消失，对侧肢体活动部分丧失。同侧肢体的倾斜反射反应看起来正常，不过通常需要通过给予左旋多巴来提高标本的背景兴奋性，以便观察到反射。相比之下，对侧肢体在低刺激频率下的反应出现了180度的相位反转，这意味着完整猫的反射接受了交叉的耳石 - 脊髓输入。从脊髓损伤尾侧的节段记录到的颈部伸肌夹肌和二腹肌的反应相对未受影响。
