Abernathy C O, Bhathena S J, Recant L, Zimmerman H J, Utili R
Horm Metab Res. 1982 Sep;14(9):468-71. doi: 10.1055/s-2007-1019049.
The effects of acute and chronic endotoxin treatment on the plasma levels of insulin and glucagon and their binding to rat liver plasma membranes were examined. Both acute and chronic endotoxin administration increased plasma glucagon levels and decreased the glucagon to insulin molar ratio. Acute, but not chronic, endotoxin decreased blood glucose and insulin levels. Glucagon binding was increased in membranes prepared from the acutely treated rats. However, in membranes obtained from rats treated chronically with endotoxin, only insulin binding was increased. The increases in the binding of both insulin and glucagon were the result of increases in receptor sites.
研究了急性和慢性内毒素处理对大鼠血浆胰岛素和胰高血糖素水平及其与大鼠肝细胞膜结合的影响。急性和慢性内毒素给药均增加血浆胰高血糖素水平并降低胰高血糖素与胰岛素的摩尔比。急性而非慢性内毒素降低血糖和胰岛素水平。急性处理大鼠制备的膜中胰高血糖素结合增加。然而，在慢性内毒素处理大鼠获得的膜中，仅胰岛素结合增加。胰岛素和胰高血糖素结合的增加是受体位点增加的结果。
