Masuma R, Tanaka Y, Omura S
J Antibiot (Tokyo). 1982 Sep;35(9):1184-93. doi: 10.7164/antibiotics.35.1184.
Addition of a natural zeolite, a known ammonium ion-trapping agent, to a complex medium resulted in a several fold increase in cerulenin production by Cephalosporium caerulens. In the presence of zeolite, ammonium ion in the medium decreased, while mycelial growth increased to a small extent, and pH values remained constant. Small amounts of ammonium bicarbonate inhibited cerulenin production without affecting mycelial growth and pH values. It is thus assumed that zeolite stimulated cerulenin production by releasing the biosynthesis from the suppression by ammonium ions in C. caerulens.
向复合培养基中添加一种天然沸石（一种已知的铵离子捕获剂），导致天蓝头孢霉产生的浅蓝菌素产量增加了几倍。在有沸石存在的情况下，培养基中的铵离子减少，而菌丝体生长略有增加，pH值保持恒定。少量碳酸氢铵抑制浅蓝菌素的产生，但不影响菌丝体生长和pH值。因此可以推测，沸石通过解除铵离子对天蓝头孢霉生物合成的抑制作用来刺激浅蓝菌素的产生。
