Fulton B P
Neuroscience. 1982;7(9):2117-24. doi: 10.1016/0306-4522(82)90123-3.
Acetylcholine (greater than or equal to 10(-5) M) applied in the bathing medium to the excitatory nerve-muscle junction of the locust caused a dose-dependent increase in the frequency of spontaneous miniature potentials and in the mean quantal content of evoked potentials. The statistical characteristics of the spontaneous release process were also modified, high frequency bursts of spontaneous potentials and "giant' miniature potentials occurring in the presence of acetylcholine. The response, which was dependent on extracellular calcium concentration, consisted of two distinct phases; these could be induced or abolished selectively by nicotinic and muscarinic drugs, respectively. The results suggest the presence, in low density, of two types of cholinergic receptors on the excitatory motor nerve terminals of the locust. The acetylcholine-induced channels may admit calcium ions. The possible role of these presynaptic receptors is discussed.
将浓度大于或等于10⁻⁵ M的乙酰胆碱施加于蝗虫兴奋性神经肌肉接头的浸泡介质中，可使自发微小电位的频率以及诱发电位的平均量子含量呈剂量依赖性增加。自发释放过程的统计特征也发生了改变，在乙酰胆碱存在的情况下会出现高频的自发电位爆发和“巨大”微小电位。该反应依赖于细胞外钙浓度，由两个不同阶段组成；这两个阶段可分别被烟碱样和毒蕈碱样药物选择性诱导或消除。结果表明，蝗虫兴奋性运动神经末梢上低密度存在两种胆碱能受体。乙酰胆碱诱导的通道可能允许钙离子进入。文中讨论了这些突触前受体的可能作用。
