Morris J A, O'Grady J P, Hamilton C J, Davidson E C
Am J Obstet Gynecol. 1978 Feb 15;130(4):379-84. doi: 10.1016/0002-9378(78)90276-4.
We serially tested 26 healthy, young, nulliparous patients, while they were maintained in the left lateral recumbent position, during a four-week interval (29 to 32 weeks), with progressive increments of angiotensin-II (A-II) 2.0 to 15.0 ng. per kilogram per minute). Blood pressure was recorded with an ultrasound device. All patients were followed through delivery. Three patients (12 per cent) developed pregnancy-induced hypertension (PIH); only one of these demonstrated enhanced vasoreactivity prior to PIH. Conversely, 13 patients who did not develop PIH demonstrated enhanced vasoreactivity at least once during the testing interval. Comparison of results obtained from one week to the next was evaluated in 57 test pairs; discordant data, i.e. reaction to less than 8 ng. per kilogram per minute one week and nonreaction the next, was observed in 17 pairs (30 per cent). We conclude that assessment of the risk of PIH, with the use of the diastolic pressor response to infused A-II, is unreliable.
我们对26名健康、年轻、未生育的患者进行了连续测试，在为期四周的时间间隔（29至32周）内，让她们保持左侧卧位，同时逐步增加血管紧张素II（A-II）的剂量，从2.0纳克/千克/分钟增加到15.0纳克/千克/分钟。使用超声设备记录血压。所有患者均随访至分娩。三名患者（12%）发生了妊娠高血压（PIH）；其中只有一名患者在发生PIH之前表现出血管反应性增强。相反，13名未发生PIH的患者在测试期间至少有一次表现出血管反应性增强。对57个测试组进行了从一周到下一周的结果比较评估；在17组（30%）中观察到了不一致的数据，即一周对低于8纳克/千克/分钟的反应与下一周无反应。我们得出结论，利用对注入A-II的舒张压升压反应来评估PIH风险是不可靠的。
