接受苯妥英治疗的癫痫患者体内的巨细胞病毒抗体。

Cytomegalovirus antibodies in epileptics receiving diphenylhydantoin.

作者信息

Andersen P, Alacam R, Andersen I, Andersen H K

出版信息

Acta Neurol Scand. 1982 Nov;66(5):561-7. doi: 10.1111/j.1600-0404.1982.tb03143.x.

DOI:10.1111/j.1600-0404.1982.tb03143.x

Abstract

Cytomegalovirus (CMV) antibodies were determined by indirect haemagglutination in 53 epileptics receiving long-term diphenylhydantoin (DPH) therapy and in 53 matched controls. Absorption of serum IgG, IgA and IgM performed in 12 sera showed that the antibodies were of the IgG class. A decreased incidence of high CMV antibody titres (greater than or equal to 320) was found in epileptics (11.3%) compared with controls (34.0%) (0.02 greater than P greater than 0.01), whereas antibody titres greater than or equal to 40 were found in 37.7% of epileptics and in 45.3% of controls (n.s.). The CMV antibody incidence and titre range were similar in patients with symptomatic (37.9%) and idiopathic (37.5%) epilepsy, suggesting that the DPH treatment was responsible for the decreased antibody occurrence in patients. No correlation between CMV antibody titres and the serum immunoglobulin levels or the DPH concentration or clearance could be established in the epileptics.

摘要

采用间接血凝法检测了53例接受长期苯妥英（DPH）治疗的癫痫患者及53例配对对照者的巨细胞病毒（CMV）抗体。对12份血清进行的血清IgG、IgA和IgM吸收试验表明，这些抗体属于IgG类。与对照者（34.0%）相比，癫痫患者中高CMV抗体滴度（大于或等于320）的发生率降低（11.3%）（0.02＞P＞0.01），而癫痫患者中有37.7%、对照者中有45.3%的抗体滴度大于或等于40（无统计学意义）。症状性癫痫患者（37.9%）和特发性癫痫患者（37.5%）的CMV抗体发生率和滴度范围相似，提示DPH治疗导致患者抗体出现率降低。在癫痫患者中，未发现CMV抗体滴度与血清免疫球蛋白水平、DPH浓度或清除率之间存在相关性。