Mira J G, Fullerton G D, Wescott W B
Acta Radiol Oncol. 1982;21(3):151-4. doi: 10.3109/02841868209133999.
Dose and initial flow rate are two of several factors that influence the outcome of xerostomia when irradiating head and neck tumors. These two parameters were analysed in 11 irradiated patients where most salivary glands were in the radiation field. Unstimulated whole saliva samples were collected before, during and after the irradiation. The results indicate a statistically significant linear correlation between initial saliva flow rate and the accumulated dose causing irreversible xerostomia. This phenomenon is explained. A diagram is made that could be used (in head and neck tumors where one side could be spared) as a indicator of the maximum dose the salivary glands in the contralateral non-involved side can receive before reaching irreversible dryness.
剂量和初始流速是影响头颈部肿瘤放疗时口干症结果的几个因素中的两个。在11例接受放疗的患者中分析了这两个参数，这些患者的大多数唾液腺都在辐射野内。在放疗前、放疗期间和放疗后收集未刺激的全唾液样本。结果表明，初始唾液流速与导致不可逆口干症的累积剂量之间存在统计学上显著的线性相关性。对此现象进行了解释。绘制了一张图表，可用于（在一侧可免受照射的头颈部肿瘤中）作为对侧未受累侧唾液腺在达到不可逆干燥之前所能接受的最大剂量的指标。
