Strender L E, Petrini B, Blomgren H, Wasserman J, Wallgren A, Baral E
Acta Radiol Oncol. 1982;21(4):217-24. doi: 10.3109/02841868209134009.
The influence on the blood lymphocyte population of two types of postoperative adjuvant chemotherapy regimes given to patients with large breast tumors or involved axillary lymph nodes have been examined. Cyclic treatment with a combination of chlorambucil, methotrexate and 5-fluorouracil was more myelotoxic and required more extensive dose reductions than treatment with cyclophosphamide, methotrexate and 5-fluorouracil with the dosage used. Both treatments reduced the size of the blood lymphocyte population and changed its cellular composition, as defined by rosette tests, to approximately the same extent. Response of the lymphocytes to specific and non-specific mitogens were also affected to approximately the same extent. A comparison of the clinical value between the two treatments has not yet been performed.
已对给予患有大乳腺肿瘤或腋窝淋巴结受累患者的两种术后辅助化疗方案对血液淋巴细胞群体的影响进行了研究。与使用环磷酰胺、甲氨蝶呤和5-氟尿嘧啶的常规剂量治疗相比，苯丁酸氮芥、甲氨蝶呤和5-氟尿嘧啶联合的循环治疗对骨髓的毒性更大，需要更广泛地降低剂量。两种治疗均减小了血液淋巴细胞群体的规模，并改变了其细胞组成（通过玫瑰花结试验定义），程度大致相同。淋巴细胞对特异性和非特异性有丝分裂原的反应也受到大致相同程度的影响。尚未对两种治疗的临床价值进行比较。
