Healy T E, Palmer J P
Br J Anaesth. 1982 Dec;54(12):1307-11. doi: 10.1093/bja/54.12.1307.
Results from in vitro experiments, using the hypogastric nerve--vas deferens preparation, and the phrenic nerve--hemidiaphragm preparation of the guineapig, have been used to determine the separation between the neuromuscular and ganglionic blocking effects of atracurium and tubocurarine. Regression lines were used to calculate the concentrations of each drug (99% confidence limits) which would produce a 50% blockade (EC50) of ganglionic and neuromuscular transmission. The equipotent molar ratio, using EC50 values, for ganglionic/neuromuscular blockade was 48 for atracurium and 9.4 for tubocurarine.
利用豚鼠的腹下神经 - 输精管标本以及膈神经 - 半膈肌标本进行的体外实验结果，已用于确定阿曲库铵和筒箭毒碱在神经肌肉阻断和神经节阻断作用之间的差异。采用回归线来计算每种药物产生神经节和神经肌肉传递50%阻断作用（EC50）时的浓度（99%置信限）。根据EC50值计算，阿曲库铵神经节/神经肌肉阻断的等效摩尔比为48，筒箭毒碱为9.4。
