可乐定对大鼠苯丙胺行为效应的调节作用。

Modulation of the behavioral effects of amphetamine in rats by clonidine.

作者信息

Mueller K, Nyhan W L

出版信息

Eur J Pharmacol. 1982 Sep 24;83(3-4):339-42. doi: 10.1016/0014-2999(82)90274-6.

Abstract

Clonidine (0.01, 0.05, 0.5 mg/kg) dramatically reduced the locomotor response to amphetamine (2 mg/kg) in a dose related fashion. In contrast, the same doses of clonidine had no effect on locomotions produced by a higher dose of amphetamine (6 mg/kg). Clonidine also had no effect on stereotyped head movements or the duration of the behavioral response to amphetamine. The lower dose of clonidine reduced amphetamine induced licking/biting while the two higher doses potentiated amphetamine induced licking/biting. Thus the behavioral effects of clonidine vary depending upon the dose of amphetamine and the particular behavior selected for study. The known neurochemical effects of clonidine do not account for this phenomenon.

摘要

可乐定（0.01、0.05、0.5毫克/千克）以剂量相关的方式显著降低了对苯丙胺（2毫克/千克）的运动反应。相比之下，相同剂量的可乐定对高剂量苯丙胺（6毫克/千克）引起的运动没有影响。可乐定对刻板的头部运动或对苯丙胺行为反应的持续时间也没有影响。较低剂量的可乐定减少了苯丙胺诱导的舔舐/咬噬行为，而较高的两个剂量则增强了苯丙胺诱导的舔舐/咬噬行为。因此，可乐定的行为效应因苯丙胺剂量和所选研究的特定行为而异。可乐定已知的神经化学效应无法解释这一现象。