用于肝脏和脾脏计算机断层扫描的碘油乳剂13的生物分布研究。

Biodistribution study of Ethiodized Oil Emulsion 13 for computed tomography of the liver and spleen.

作者信息

Vermess M, Lau D H, Adams M D, Hopkins R M, Hoey G B, Grimes G, Chatterji D C, Girton M, Doppman J L

出版信息

J Comput Assist Tomogr. 1982 Dec;6(6):1115-9. doi: 10.1097/00004728-198212000-00011.

DOI:10.1097/00004728-198212000-00011

Abstract

Biodistribution studies were conducted with a new intravenous lipoid contrast material currently undergoing clinical trials in four hospitals. The contrast material selectively opacifies the liver and spleen for computed tomographic examination. The experiments were performed on rats with 125I-labeled ethiodized oil emulsion. The study showed that the liver accumulates nearly 80% of the injected iodine within 15 min of the injection and retains a high concentration over 3 h. The second highest concentration was found in the spleen. More than 99% of the iodine is eliminated from the liver and spleen within 48 h, primarily through the kidneys.

摘要

使用一种正在四家医院进行临床试验的新型静脉注射类脂质造影剂进行了生物分布研究。这种造影剂在计算机断层扫描检查中能选择性地使肝脏和脾脏显影。实验是用125I标记的乙碘油乳剂在大鼠身上进行的。研究表明，肝脏在注射后15分钟内积聚了近80%注入的碘，并在3小时内保持高浓度。脾脏中的碘浓度次之。48小时内，超过99%的碘从肝脏和脾脏中消除，主要通过肾脏。