Fujiwara T, Katayama K, Tojo S
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Nov;34(11):1889-98.
Plasma cyclic nucleotides in some physiological conditions were measured in normal women and the changes of cyclic AMP were studied after the loading of gonadotropins in normal and castrated women. We demonstrated a circadian rhythm of cyclic AMP and its variation during menstrual cycle in normal women and also demonstrated its significant increase in pregnant women. But there was no significant variation of plasma cyclic GMP levels in those physiological conditions. Plasma cyclic AMP was increased by the simultaneous administration of HMG and HCG in both normal and castrated women. However, individual administration of HMG or HCG demonstrated that it was HCG that caused that increase in plasma cyclic AMP even in castrated women. To examine the extragonadal effects of HCG, cortisol, triiodothyronine (T3), thyroxine (T4) in the plasma were measured after the loading of HCG. The plasma cortisol level was influenced by HCG in neither normal nor castrated women. HCG did not cause any change of T3 or T4 in normal women; however it caused a marked increase in T3 with a small decrease in T4 in castrated women.
在正常女性中测量了某些生理状况下的血浆环核苷酸，并研究了正常女性和去势女性注射促性腺激素后环磷酸腺苷（cAMP）的变化。我们证实了正常女性中cAMP的昼夜节律及其在月经周期中的变化，还证实了孕妇体内cAMP显著升高。但在这些生理状况下，血浆环磷酸鸟苷（cGMP）水平无显著变化。在正常女性和去势女性中，同时注射人绝经期促性腺激素（HMG）和人绒毛膜促性腺激素（HCG）可使血浆cAMP升高。然而，单独注射HMG或HCG表明，即使在去势女性中，也是HCG导致血浆cAMP升高。为了研究HCG的性腺外作用，注射HCG后测量了血浆中的皮质醇、三碘甲状腺原氨酸（T3）、甲状腺素（T4）。无论是正常女性还是去势女性，血浆皮质醇水平均不受HCG影响。在正常女性中，HCG不会引起T3或T4的任何变化；然而，在去势女性中，它会导致T3显著升高，T4略有下降。
