Racagni G, Apud J A, Cocchi D, Locatelli V, Muller E E
Life Sci. 1982 Aug 30;31(9):823-38. doi: 10.1016/0024-3205(82)90537-9.
Anatomical and biochemical studies have identified a hypothalamic tubero-infundibular GABAergic system, which plays a functional role on anterior pituitary hormone secretion. Experimental and clinical evidence support the presence of a dual component in the action of GABA; one mediated via the central nervous system and the other exerted directly at the anterior pituitary level. The two sites of action may be responsible for the excitatory and inhibitory effects of GABA on pituitary hormone and especially prolactin secretion. The future characterization of this system will provide a better understanding of the involvement of GABA in the physiology of anterior pituitary hormone secretion and will contribute to the development of new pharmacological agents for the therapy of neuroendocrine disorders.
解剖学和生物化学研究已经确定了一个下丘脑结节-漏斗γ-氨基丁酸能系统，该系统对垂体前叶激素分泌发挥功能性作用。实验和临床证据支持γ-氨基丁酸作用存在双重成分；一种通过中枢神经系统介导，另一种直接作用于垂体前叶水平。这两个作用位点可能是γ-氨基丁酸对垂体激素尤其是催乳素分泌产生兴奋和抑制作用的原因。对该系统未来的特性描述将有助于更好地理解γ-氨基丁酸在垂体前叶激素分泌生理学中的作用，并将有助于开发用于治疗神经内分泌疾病的新型药物。
