犬免疫血清对犬埃立克体在非免疫犬巨噬细胞内生长的影响。
Effect of canine immune serum on the growth of Ehrlichia canis within nonimmune canine macrophages.
作者信息
Lewis G E, Hill S L, Ristic M
出版信息
Am J Vet Res. 1978 Jan;39(1):71-6.
The effect of canine immune serum (CIS) on the growth of Ehrlichia canis was studied in macrophage cultures derived from peripheral blood monocytes of normal dogs. Ehrlichiae treated with canine normal serum and then introduced into normal macrophage cultures maintained in canine normal serum multiplied within the macrophages and destroyed them. Immune serum, collected from E canis carrier dogs, suppressed ehrlichial growth in normal macrophages. An inverse relationship existed between the amount of CIS to which ehrlichiae were exposed and the growth of the organism in normal macrophages. The anti-E canis activity was most prevalent in the 7-S fraction of immune serum. Fresh CIS had a greater suppressive effect on the growth of E canis than did heat-inactivated CIS. Antibody cytophilic for canine monocyte-derived macrophages was not detected in CIS.
在源自正常犬外周血单核细胞的巨噬细胞培养物中，研究了犬免疫血清（CIS）对犬埃立克体生长的影响。用犬正常血清处理埃立克体，然后将其引入在犬正常血清中维持的正常巨噬细胞培养物中，埃立克体在巨噬细胞内繁殖并将其破坏。从犬埃立克体携带犬收集的免疫血清可抑制正常巨噬细胞中埃立克体的生长。埃立克体接触的CIS量与该生物体在正常巨噬细胞中的生长之间存在反比关系。抗犬埃立克体活性在免疫血清的7-S部分中最为普遍。新鲜的CIS对犬埃立克体生长的抑制作用比热灭活的CIS更大。在CIS中未检测到对犬单核细胞衍生巨噬细胞具有亲细胞性的抗体。
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