Schaeffer C A, Nathanson D C, Cegavske C F, Roemer R A
Peptides. 1982 Sep-Oct;3(5):715-9. doi: 10.1016/0196-9781(82)90003-1.
Subjects were conditioned/extinguished under four experimental conditions using either MSH/ACTH 4-10(A) or diluent (D): D/D, D/A, A/D, and A/A. The major question investigated was whether or not the peptide has an effect on this classically-conditioned behavior similar to that reported for instrumental conditioning paradigms. The results indicated that it does not. An effect was seen on performance, not on learning or attentional processes. Animals treated with the peptide performed more poorly (i.e., displayed fewer conditioned responses) during both acquisition and extinction. In addition, there was an apparent residual effect of the peptide that lasted 24 but not 48 hours.
在四种实验条件下，使用促黑素/促肾上腺皮质激素4 - 10（A）或稀释剂（D）对实验对象进行条件反射/消退训练：D/D、D/A、A/D和A/A。所研究的主要问题是该肽是否对这种经典条件反射行为有影响，类似于在工具性条件反射范式中所报道的那样。结果表明它没有。观察到的是对表现有影响，而不是对学习或注意力过程有影响。用该肽处理的动物在习得和消退过程中表现更差（即表现出的条件反应更少）。此外，该肽有明显的残留效应，持续24小时但不是48小时。
