Enhancement of osmotic- and hypovolemic-induced drinking by chlordiazepoxide in rats is blocked by naltrexone. - Suppr | 超能文献

Enhancement of osmotic- and hypovolemic-induced drinking by chlordiazepoxide in rats is blocked by naltrexone.

作者信息

Cooper S J

出版信息

Pharmacol Biochem Behav. 1982 Nov;17(5):921-5. doi: 10.1016/0091-3057(82)90473-7.

DOI:10.1016/0091-3057(82)90473-7

Abstract

Recent reports indicate that benzodiazepine-induced hyperphagia can be antagonised by naloxone, an opiate antagonist. Benzodiazepines are also known to facilitate water ingestion in water-deprived rats, and the present study showed that in addition, benzodiazepine treatment can enhance drinking which is elicited by an osmotic thirst stimulus (2 M hypertonic saline) or by a hypovolemic thirst stimulus (20% polyethylene glycol). In both cases, low dose levels of naltrexone (also an opiate antagonist) dose-dependently suppressed the facilitation of thirst-aroused drinking by chlordiazepoxide. Taken with recent biochemical data these behavioral results indicate that the enhancement of ingestive responses by benzodiazepines may depend upon a naloxone-reversible release of endogenous opioid peptides.

摘要

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