Jackson G G
Yale J Biol Med. 1982 May-Aug;55(3-4):369-74.
Antiviral chemotherapy has been too long perceived as being relatively impossible. Such notions adversely affect the acquisition of important specific clinical information, whereas much new knowledge is available about viral replication and cell biology which enhances the prospects for effective chemotherapy. Some immediate goals can be recognized that will further determine the ability to influence viral infections and properly interpret the drug effects. In recent controlled observations there is reason for expectant optimism, but the demonstration of antiviral chemotherapy is both disease- and host-dependent, with important nonpharmacologic aspects. Rapid specific and sensitive diagnostic tests are of paramount importance; that they can be devised is a generally accepted conclusion among virologists. Problems in the scientific evaluation of antiviral chemotherapy in man have led to the recommendations of compounds that have no proved effect; amantadine, Ara A, and interferon, however, have been shown to be efficacious. Acyclovir and bromvinyldeoxyuridine have demonstrated virus-directed chemotherapy with impressive specificity. The frontier of antiviral chemotherapy holds great promise for additional learning and improved health through the implementation of developing knowledge.
抗病毒化疗长期以来一直被认为相对难以实现。这种观念对获取重要的特定临床信息产生了不利影响，而目前已有许多关于病毒复制和细胞生物学的新知识，这增加了有效化疗的前景。可以确定一些近期目标，这些目标将进一步决定影响病毒感染的能力并正确解释药物效果。在最近的对照观察中，有理由抱有期待性的乐观态度，但抗病毒化疗的效果既取决于疾病，也取决于宿主，还涉及重要的非药理学方面。快速、特异且灵敏的诊断测试至关重要；病毒学家普遍认为能够设计出这样的测试。人体抗病毒化疗科学评估中的问题导致推荐了一些未被证实有效果的化合物；然而，金刚烷胺、阿糖腺苷和干扰素已被证明是有效的。阿昔洛韦和溴乙烯脱氧尿苷已显示出具有令人印象深刻的特异性的病毒导向化疗。通过应用不断发展的知识，抗病毒化疗的前沿领域在进一步学习和改善健康方面有着巨大的前景。
