Jones B, Hrabovsky E, Kiviat N, Breslow N
Am J Clin Oncol. 1982 Oct;5(5):545-50.
Eighteen of the patients randomized for treatment according to the first and second National Wilms' Tumor Studies have developed clinically evident tumor in the contralateral kidney subsequent to the initial diagnosis. Only seven of 18 had an adequate exploration of the opposite kidney during the initial surgery and of these seven, four had abnormal findings. Thirteen of 18 cases showed some form of nephroblastomatosis histologically. The original tumors in six and possibly seven were multicentric in origin. While metachronous Wilms' tumors are an unusual occurrence, the prognosis is ominous with only seven of 18 surviving free of disease. The outlook might be improved with adequate attention to the surgical and histologic details during the initial diagnostic procedures.
根据第一和第二次全国肾母细胞瘤研究随机分组接受治疗的18例患者，在初次诊断后对侧肾脏出现了临床上明显的肿瘤。18例中只有7例在初次手术时对另一侧肾脏进行了充分探查，这7例中有4例发现异常。18例中有13例在组织学上表现为某种形式的肾母细胞瘤病。6例甚至可能7例的原发肿瘤起源于多中心。虽然异时性肾母细胞瘤并不常见，但预后不佳，18例中只有7例无病存活。在初次诊断过程中充分关注手术和组织学细节，可能会改善预后。
