Warkel R L, Helwig E B
Arch Dermatol. 1978 Feb;114(2):198-203.
Apocrine tumors from the axilla of 12 patients were studied clinically and pathologically. Based on histologic features, two tumors were classified as adenomas and ten as adenocarcinomas. All of the neoplasms were characterized by a glandular arrangement of large cells with abundant eosinophillic cytoplasm and evidence of decapitation secretion. The cytoplasm of the tumor cells contained PAS-positive, diastase-resistant granules. Intracytoplasmic particles of iron were demonstrable in three of ten tumors. Follow-up was available for all 12 patients. The two patients with apocrine adenoma are alive and well. Two patients with adenocarcinoma died of unrelated causes shortly after diagnosis. Of the remaining eight patients with adenocarcinoma, three have died of disease, and one is living with skeletal metastasis. A correlation appears to exist between tumor differentiation and prognosis.
对12例患者腋窝大汗腺肿瘤进行了临床和病理研究。根据组织学特征，2例肿瘤被分类为腺瘤，10例为腺癌。所有肿瘤的特征是大细胞呈腺管状排列，胞质丰富嗜酸性，并有断头分泌的证据。肿瘤细胞的胞质内含有PAS阳性、抗淀粉酶颗粒。10例肿瘤中有3例可检测到胞质内铁颗粒。12例患者均有随访资料。2例大汗腺腺瘤患者健在。2例腺癌患者在诊断后不久死于无关原因。其余8例腺癌患者中，3例死于疾病，1例有骨骼转移存活。肿瘤分化与预后之间似乎存在相关性。
