Bugnon C, Fellmann D, Gouget A, Cardot J
C R Seances Soc Biol Fil. 1982;176(4):503-10.
Immunocytochemical study of the pro-opio-melano-cortin neurones in rat fetuses and newborns indicates that: 1) they appear precociously in the mediobasal hypothalamus, as early as day 13 of fetal development, that is to say 3 days before pro-opio-melano-cortin-containing pituitary cells; 2) between day 13 and day 17 they display synchronous changes in their intracellular patterns of immunoreactivity, arguing in favour of their cyclic secreting activity, which precedes the establishing of their projections; 3) beginning with day 18 until birth, the somatal immunoreactivity disappears transitorily; during the same period and the first postnatal days, their immunoreactive fibres extend in various brain regions.
对大鼠胎儿和新生儿中促阿片-黑素细胞皮质素神经元的免疫细胞化学研究表明：1）它们早在胎儿发育第13天就在下丘脑中间基底部早熟出现，也就是说比含促阿片-黑素细胞皮质素的垂体细胞早3天；2）在第13天到第17天之间，它们细胞内免疫反应模式呈现同步变化，这表明它们具有周期性分泌活动，且这种活动先于其投射的建立；3）从第18天开始直至出生，体细胞免疫反应性暂时消失；在同一时期及出生后的头几天，它们的免疫反应性纤维延伸至不同脑区。
