Hardy J
Can J Neurol Sci. 1982 Nov;9(4):375-80.
The recent improvements in transsphenoidal microsurgery have once again placed the emphasis on the basophilic adenoma of the pituitary as the etiology of the disease originally described by Harvey Cushing fifty years ago. In 75 operated cases, tumors were found in 60 cases: 52 were microadenomas, 4 were larger adenomas and 4 were invasive. In 15 cases, no tumor was found at surgery; a selective partial central hypophysectomy was performed in 11 cases and a total hypophysectomy in 4. Among the latter, 3 additional microadenomas were found at pathology. The majority of the microadenomas were located in the center of the gland most often near or within the neural lobe. In 59 patients with a non invasive tumor, initial cure was obtained in 52 (88%); only 1 of the 4 patients with an invasive tumor was cured. In the 12 cases without surgical or pathological tumor, partial or total hypophysectomy resulted in 10 cures (83%).
经蝶窦显微手术最近的进展再次将垂体嗜碱性腺瘤视为该病的病因，该病最初由哈维·库欣于50年前描述。在75例接受手术的病例中，60例发现有肿瘤：52例为微腺瘤，4例为较大腺瘤，4例为侵袭性肿瘤。15例手术中未发现肿瘤；11例行选择性部分垂体中央切除术，4例行全垂体切除术。在后者中，病理检查又发现3例微腺瘤。大多数微腺瘤位于腺垂体中央，最常见于神经叶附近或神经叶内。59例非侵袭性肿瘤患者中，52例（88%）初次治愈；4例侵袭性肿瘤患者中仅1例治愈。在12例无手术或病理证实肿瘤的病例中，部分或全垂体切除术导致10例治愈（83%）。
