Decima E E, Morales F R
Exp Neurol. 1983 Feb;79(2):532-51. doi: 10.1016/0014-4886(83)90231-5.
We investigated the long-lasting effects of severing an axonal branch on the function of the synapses made by the remaining branches of the "partially" transected axon. The experimental model used was the monosynaptic reflex pathway of the cat lumbar cord. Preliminary surgical procedures consisted of a dorsal column (DC) hemisection at the L3--L4 level on the left side under aseptic conditions. During the final recording experiments, the monosynaptic reflex (MSR) of the operated and normal (control) side was studied in motorpools in the L7 and S1 segments. The results indicate that the DC operation produced on the operated side (a) an enhancement of the MSR and (b) a more powerful postetanic potentiation, both of the "early" and "late" varieties. These effects were seen as early as 34 days and as late as 121 days after the original DC hemisection. Control experiments were carried out to exclude denervation supersensitivity, supraspinal effects, and normal asymmetries between sides as the mechanism underlying these effects. A presynaptic change in the operated axons, resulting in an increased synaptic efficiency, is proposed as the possible mechanism.
我们研究了切断轴突分支对“部分”横断轴突其余分支所形成突触功能的长期影响。所采用的实验模型是猫腰髓的单突触反射通路。初步手术步骤包括在无菌条件下于左侧L3 - L4水平进行背柱（DC）半横切。在最后的记录实验中，在L7和S1节段的运动神经元池研究手术侧和正常（对照）侧的单突触反射（MSR）。结果表明，DC手术在手术侧产生了（a）MSR增强以及（b）“早期”和“晚期”两种类型的更强大的强直后增强。这些效应最早在最初的DC半横切后34天出现，最晚在121天出现。进行了对照实验以排除去神经超敏反应、脊髓上的影响以及两侧之间正常的不对称性作为这些效应的潜在机制。有人提出手术侧轴突的突触前变化导致突触效率增加是可能的机制。
