抗血清对纤维化性二氧化硅释放的巨噬细胞因子的中和作用。

Neutralization of the fibrogenic silica-released macrophage factor by antiserum.

作者信息

Aalto M, Viljanen M, Kulonen E

出版信息

Exp Pathol. 1982;22(3):181-4. doi: 10.1016/s0232-1513(82)80007-8.

Abstract

Antiserum against the fibrogenic factor from the culture medium of silica-treated rat macrophages was produced in rabbits. In dilution 1: 10,000 the antiserum cancelled the stimulating effect of the culture medium of rat macrophages on the 3H-proline incorporation into granulation-tissue fibroblasts. The rabbit antiserum had variable effects on the stimulation by the media of silica-treated human monocytes, but no effect on the media of cultured human SU-DHL-2-cells.

摘要

用二氧化硅处理过的大鼠巨噬细胞培养基中的致纤维化因子抗血清是在兔体内制备的。该抗血清在1:10000稀释度下，可消除大鼠巨噬细胞培养基对3H-脯氨酸掺入肉芽组织成纤维细胞的刺激作用。兔抗血清对二氧化硅处理过的人单核细胞培养基的刺激作用有不同影响，但对培养的人SU-DHL-2细胞的培养基无影响。