Inhibitory characteristics of indomethacin on the activation of K+-dependent p-nitrophenylphosphatase by both Na+ and ATP in vitro.
作者信息
Koike K, Terao N, Takiguchi H
出版信息
Gen Pharmacol. 1982;13(6):515-8. doi: 10.1016/0306-3623(82)90027-1.
PMID:6295873
Abstract
- The activation of K+-NPPase by both Na+ and ATP was inhibited by indomethacin in vitro. 2. Indomethacin concentration required for 50% inhibition was 6.25 X 10(-4) M. 3. Inhibition manners of indomethacin for Na+ and ATP were competitive type and noncompetitive type, respectively. 4. The Ki values for indomethacin for Na+ and ATP were 1.4 X 10(-4) M and 8.8 X 10(-4) M, respectively. 5. The inhibitory effect of indomethacin was reversible.
摘要
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