Wieczorek W J, D'Mello A, Assem E S
Int J Immunopharmacol. 1982;4(6):507-16. doi: 10.1016/0192-0561(82)90030-3.
In conscious guinea-pigs isoprenaline, adrenaline and salbutamol protected the animals against egg albumin and histamine microshock in a dose-dependent manner. Chronic aerosol pretreatment three times daily with adrenaline or isoprenaline, but not with salbutamol, enhanced the acute dose protection against egg albumin microshock, but there was no enhancement when the bronchodilators were given six times daily. Aminophylline when administered three times daily enhanced the protective effect of an acute dose of adrenaline. With histamine microshock, desensitization occurred to adrenaline, when given three and six times daily, and to isoprenaline, when given six times daily, but not to salbutamol. Cross-desensitization could be induced to adrenaline by isoprenaline but not by salbutamol. The data indicate that, depending on the experimental conditions, enhancement of or desensitization to the effects of bronchodilators could be shown in conscious guinea-pigs.
在清醒的豚鼠中，异丙肾上腺素、肾上腺素和沙丁胺醇能以剂量依赖的方式保护动物免受蛋清和组胺微休克的影响。每天三次用肾上腺素或异丙肾上腺素进行慢性气雾剂预处理，而不是用沙丁胺醇，可增强对蛋清微休克的急性剂量保护作用，但当支气管扩张剂每天给药六次时则无增强作用。氨茶碱每天三次给药可增强急性剂量肾上腺素的保护作用。对于组胺微休克，每天三次和六次给予肾上腺素以及每天六次给予异丙肾上腺素时会出现脱敏现象，但给予沙丁胺醇时不会出现。异丙肾上腺素可诱导对肾上腺素的交叉脱敏，但沙丁胺醇不能。数据表明，根据实验条件，在清醒的豚鼠中可显示支气管扩张剂作用的增强或脱敏。
