Kraut J A, Gordon E M, Ransom J C, Coburn J W, Kurokawa K
J Clin Endocrinol Metab. 1983 Mar;56(3):619-22. doi: 10.1210/jcem-56-3-619.
To examine the effect of prolonged metabolic acidosis on the responsiveness of end organs to PTH, we measured the changes in serum ionized calcium and the urinary excretion of calcium and phosphorus in response to a 10-h infusion of parathyroid extract (PTE) before and after 9 days of metabolic acidosis. During the first hours of PTE infusion, the increases in ionized calcium were slower during acidosis, but the maximal increments in ionized calcium (0.5 +/- 0.1 and 0.4 +/- 0.1 mg/dl, respectively) were not different. Moreover, the PTE-induced increments in the fractional excretion of phosphate during acidosis and the control study were not different. Fractional excretion of calcium before the infusion of PTE was higher in acidosis than in control (3.7 +/- 0.3% compared to 0.8 +/- 0.3%; P less than 0.01). However, at 10 h of the infusion, when the maximal effect of PTE was observed, the fractional excretions of calcium in control and acidosis were not significantly different. These data suggest that prolonged metabolic acidosis has little or no effect on bone or renal responsiveness to PTH.
为了研究长期代谢性酸中毒对终末器官对甲状旁腺激素（PTH）反应性的影响，我们在代谢性酸中毒9天前后，测量了静脉输注甲状旁腺提取物（PTE）10小时期间血清离子钙的变化以及钙和磷的尿排泄量。在输注PTE的最初几个小时内，酸中毒期间离子钙的升高较慢，但离子钙的最大增量（分别为0.5±0.1和0.4±0.1mg/dl）并无差异。此外，酸中毒期间和对照研究中PTE诱导的磷排泄分数增加并无差异。输注PTE前酸中毒时钙的排泄分数高于对照组（分别为3.7±0.3%和0.8±0.3%；P<0.01）。然而，在输注10小时观察到PTE的最大效应时，对照组和酸中毒组的钙排泄分数并无显著差异。这些数据表明，长期代谢性酸中毒对骨骼或肾脏对PTH的反应性几乎没有影响。
