Drexler J
Med Hypotheses. 1982 Oct;9(4):353-60. doi: 10.1016/0306-9877(82)90073-1.
Currently, four hypotheses attempt to explain the pathogenesis of idiopathic hypercalciuria. Proposed theories include hypersecretion of parathyroid hormone, hyperabsorption of calcium by the gastrointestinal tract, hyperreabsorption of calcium by the kidney, and hyperexcretion of phosphate by the kidney. These hypotheses are more descriptive than explanatory. A new hypothesis is suggested which encompasses the divergent findings. Idiopathic hypercalciuria may result from hypersecretion of parathyroid hormone which is active at the gastrointestinal and bone target site but is partially defective at its renal site of action.
目前，有四种假说试图解释特发性高钙尿症的发病机制。提出的理论包括甲状旁腺激素分泌过多、胃肠道对钙的过度吸收、肾脏对钙的过度重吸收以及肾脏对磷酸盐的过度排泄。这些假说更多的是描述性而非解释性的。本文提出了一种新的假说，该假说涵盖了不同的研究结果。特发性高钙尿症可能是由于甲状旁腺激素分泌过多所致，这种激素在胃肠道和骨骼靶部位具有活性，但在其肾脏作用部位存在部分缺陷。
