Wiebe R H, Morris C V
Obstet Gynecol. 1983 Mar;61(3):279-84.
A plasma testosterone/androstenedione (T/A) ratio was calculated in 15 women with possible ovarian neoplasms and androgen excess and whose mean plasma concentration of testosterone approached or was greater than a twofold elevation. The T/A ratio approached unity in eight of nine patients with polycystic ovarian disease, whereas all patients with hyperthecosis and two of three patients with androgen-secreting tumors had a testosterone/androstenedione ratio above 1.5. In 13 of 16 patients with androgen-secreting tumors of the ovary reported in the literature, the testosterone/androstenedione ratio was above 1.5. An elevated testosterone/androstenedione ratio should raise the suspicion of either an ovarian androgen-secreting tumor or hyperthecosis.
对15名可能患有卵巢肿瘤且雄激素水平过高、血浆睾酮平均浓度接近或高于两倍升高水平的女性，计算了血浆睾酮/雄烯二酮（T/A）比值。在9例多囊卵巢疾病患者中，有8例的T/A比值接近1，而所有卵泡膜增生患者以及3例雄激素分泌性肿瘤患者中的2例，其睾酮/雄烯二酮比值高于1.5。在文献报道的16例卵巢雄激素分泌性肿瘤患者中，有13例的睾酮/雄烯二酮比值高于1.5。睾酮/雄烯二酮比值升高应引起对卵巢雄激素分泌性肿瘤或卵泡膜增生的怀疑。
