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[念珠菌和曲霉菌引起的急性真菌性肺病(病例报告)]

[Acute fungal pneumopathy caused by Candida and Aspergillus (case report)].

作者信息

Galbenu P, Ghinescu S

出版信息

Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1982 Jul-Sep;31(3):245-50.

PMID:6296980
Abstract

A case is presented, of a patient with acute fungal pneumopathy. The evolution of the disease in this 63 years male was short and rapid, characterized by fever, dyspnea, thoracic pain, muco-purulent expectoration and intense coughing. In spite of the complex treatment applied the patient died with acute cardio-respiratory failure. The radiological examination revealed micro-nodular and nodular opacities extending predominantly in the left lung. Laboratory investigations included a microbiologic study for the Koch bacillus, which was negative. The post-mortem examination revealed multiple focuses with suppurative aspects on a diffuse background of hepatization. The microscopic examination evidenced the presence in the respective focuses of abundant colonies of Candida and Aspergillus, and a hematogenic invasion with Candida and allowed to determine a diagnosis of acute pneumopathy of fungal origin as a result of a double infection with Candida and Aspergillus strains.

摘要

本文报告一例急性真菌性肺病患者。该63岁男性患者的病程短且进展迅速,表现为发热、呼吸困难、胸痛、黏液脓性咳痰和剧烈咳嗽。尽管采取了综合治疗措施,患者仍死于急性心肺功能衰竭。影像学检查显示微结节和结节状阴影,主要分布在左肺。实验室检查包括针对结核杆菌的微生物学研究,结果为阴性。尸检发现,在肝样变的弥漫背景上有多个化脓性病灶。显微镜检查证实在相应病灶中存在大量念珠菌和曲霉菌落,并发现念珠菌的血行感染,从而确定诊断为念珠菌和曲霉菌株双重感染所致的急性真菌源性肺病。

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