Stecchini M, Corrias G
Sem Hop. 1982 Dec 16;58(46):2724-6.
The neuropsychiatric manifestations of alcoholism can be amended by neutralizing the somatic effects of alcohol on nervous centers. Tiapride acts electively on the mesolimbic area. Promising results have been obtained with tiapride in the various clinical forms of alcohol intoxication. Sixty patients (40 men and 20 women) were given tiapride for abnormal symptoms due to alcohol. Tolerance was good: no side-effects were recorded, with the exception of extrapyramidal manifestations in one patient. Symptoms due to alcohol abuse were alleviated. Relief of tremor was significant. Tiapride proved helpful in anxiety and depression and caused hallucinations to disappear in 35 cases.
酒精中毒的神经精神表现可通过中和酒精对神经中枢的躯体影响来改善。硫必利选择性作用于中脑边缘系统区域。在酒精中毒的各种临床症状中,硫必利已取得了有前景的治疗效果。60例患者(40名男性和20名女性)因酒精所致异常症状接受了硫必利治疗。耐受性良好:除1例患者出现锥体外系表现外,未记录到其他副作用。酒精滥用所致症状得到缓解。震颤缓解明显。硫必利被证明对焦虑和抑郁有帮助,并使35例患者的幻觉消失。