Dagi T F, Poletti C E
Brain Res. 1983 Jan 24;259(2):229-36. doi: 10.1016/0006-8993(83)91253-2.
Cingulate cortex (CC) unit responses to hippocampal volleys and afterdischarges were studied in 4 awake unsedated squirrel monkeys using extracellular microelectrodes. Stimuli were delivered via bipolar electrodes chronically implanted bilaterally in anterior and posterior hippocampus. A total of 412 units in 21 tracks were studied and tested to single and multiple shock stimulation. Spontaneous firing rates were approximately equally distributed among slow (0.25 spikes/s), medium (2.5-10), and fast (10-25). Only 2% of cingulate units (9/412) responded orthodromically to hippocampal stimulation: 5 with initial excitation; 4 with initial inhibition. Eight responses had initial latencies from 100-200 ms; one unit a latency of 25 ms. Three units displayed periodic, almost cyclical, excitation. All unit response thresholds were 1 shock, 0.25 mA or less. Hippocampal afterdischarge activity influenced the firing pattern of 17 units: 16 showed intraictal excitation and 1 inhibition. In comparison with the preceding studies in the same model these results indicate that the influence of hippocampal stimulation on cingulate cortex is not nearly as prominent as either the fornix or non-fornix hippocampal influence on hypothalamic, preoptic, and basal forebrain structures. It is proposed that the cingulate cortex is not a prominent link in the Papez circuit.
使用细胞外微电极，在4只未使用镇静剂的清醒松鼠猴中研究了扣带回皮质（CC）对海马群峰电位和后放电的单位反应。刺激通过双侧慢性植入海马前后部的双极电极进行。共研究了21条轨迹中的412个单位，并对其进行了单次和多次电击刺激测试。自发放电率在慢（0.25个脉冲/秒）、中（2.5 - 10）和快（10 - 25）之间大致均匀分布。只有2%的扣带回单位（9/412）对海马刺激产生顺向反应：5个最初兴奋；4个最初抑制。8个反应的初始潜伏期为100 - 200毫秒；1个单位潜伏期为25毫秒。3个单位表现出周期性、几乎是循环性的兴奋。所有单位反应阈值均为1次电击，0.25毫安或更低。海马后放电活动影响了17个单位的放电模式：16个表现出发作期兴奋，1个表现出抑制。与之前在同一模型中的研究相比，这些结果表明海马刺激对扣带回皮质的影响远不如穹窿或非穹窿海马对下丘脑、视前区和基底前脑结构的影响显著。有人提出，扣带回皮质不是帕佩兹环路中的重要环节。
