灌注大鼠肾脏中谷氨酰胺氮的代谢去向
The metabolic fate of glutamine nitrogen in the perfused rat kidney.
作者信息
Ross B D, Bullock S
出版信息
Biochem J. 1978 Jan 15;170(1):177-9. doi: 10.1042/bj1700177.
Abstract
The fate of glutamine amide and amino nitrogen was determined in the perfused rat kidney. There is a deficit of about 40% in the recovery of glutamine nitrogen and NH3 in the perfusion medium. After correction for the tissue conetent of glutamine, the remaining nitrogen was fully accounted for by small amounts of NH3, glutamate, aspartate and a compound that liberated glutamate on acid hydrolysis, probably 5-oxopyrrolidine-2-carboxylate (pyroglutamate). The latter accounted for 8% of the glutamine metabolized.
摘要
在灌注的大鼠肾脏中测定了谷氨酰胺酰胺和氨基氮的命运。灌注液中谷氨酰胺氮和NH₃的回收率约有40%的亏缺。校正谷氨酰胺的组织含量后，剩余的氮完全由少量的NH₃、谷氨酸、天冬氨酸以及一种在酸水解时释放谷氨酸的化合物（可能是5-氧代吡咯烷-2-羧酸，即焦谷氨酸）所解释。后者占代谢的谷氨酰胺的8%。
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