Focan C, Schyns-Mosen J, Luyckx A, Lefebvre P
J Cancer Res Clin Oncol. 1982;104(3):197-206. doi: 10.1007/BF00406240.
The kinetics of a transplantable islet-cell tumor known to secrete paranormal hormonal compounds without any influence of usual regulatory mechanisms was studied in the golden hamster. It was found that during the 42nd diurnal period of growth, labelling and mitotic indices (peaks at midday), mean grain counts (lower at 4 a.m. and 8 a.m.), and PLM data (shift between G1 and S phase durations) varied significantly. The results are discussed in view of the discrepancy between hormonal release (unaffected by normal triggering factors) and circadian kinetics indicating the persistence of tumoral sensitivity to some control mechanisms. The theoretical importance of the diurnal variability for the correct interpretation of the internal kinetics of tumors is recalled.
在金黄仓鼠中研究了一种可移植胰岛细胞瘤的动力学，该肿瘤能分泌异常激素化合物，且不受正常调节机制的影响。研究发现，在生长的第42个昼夜周期中，标记指数和有丝分裂指数（中午达到峰值）、平均颗粒计数（凌晨4点和上午8点较低）以及PLM数据（G1期和S期持续时间之间的变化）有显著差异。鉴于激素释放（不受正常触发因素影响）与昼夜动力学之间的差异，对结果进行了讨论，这表明肿瘤对某些控制机制仍具有敏感性。文中回顾了昼夜变化对于正确解释肿瘤内部动力学的理论重要性。
