Prostaglandins enhance intercellular adhesion of Vero cells infected with herpes simplex virus.

The effect of prostaglandins (PGs) and cyclic nucleotides on adherence between uninfected Vero cells or between uninfected cells and cells infected with wild-type or syncytial strains of herpes simplex virus (HSV) was studied. In the absence of serum, PGE2 increased adhesion between uninfected cells whereas PGF2 alpha decreased it. However, both PGE2 and PGF2 alpha increased adhesion between cells infected with HSV and uninfected cells. Moreover, dibutyryl cyclic AMP increased adhesion between uninfected cells and cells infected with HSV, whereas dibutyryl cyclic GMP decreased it.