产生血管活性肠肽的神经母细胞瘤

Vasoactive intestinal peptide producing neuroblastoma.

作者信息

Cooney D R, Voorhess M L, Fisher J E, Brecher M, Karp M P, Jewett T C

出版信息

J Pediatr Surg. 1982 Dec;17(6):821-25. doi: 10.1016/s0022-3468(82)80450-8.

Abstract

The Verner-Morrison syndrome has been described in 19 previous patients with ganglioneuroma and ganglioneuroblastoma but never neuroblastoma. Its occurrence following treatment of a neuroblastoma with chemotherapy with maturation of the tumor has only been reported on one previous occasion. Our case suggests that vasoactive intestinal polypeptide may be used not only as a diagnostic indicator for the presence of a neural crest tumor but also as a marker to monitor maturation of the tumor and indicate an improving prognosis.

摘要

在之前报道的19例患有神经节神经瘤和神经节神经母细胞瘤的患者中曾描述过韦纳-莫里森综合征，但未见于神经母细胞瘤患者。肿瘤化疗后成熟的神经母细胞瘤患者出现该综合征仅在之前有过一次报道。我们的病例提示，血管活性肠肽不仅可作为神经嵴肿瘤存在的诊断指标，还可作为监测肿瘤成熟情况及提示预后改善的标志物。