Olson R D, Nies A S, Gerber J G
J Pharmacol Exp Ther. 1983 Mar;224(3):483-8.
The role of renal alpha and beta adrenoceptor activation and prostaglandin synthesis in mediating renin release to intrarenal infusions of the natural neurotransmitters, norepinephrine and epinephrine, was assessed in anesthetized mongrel dogs. Intrarenal infusions of norepinephrine and epinephrine at doses adjusted to reduce renal blood flow by 20 and 50% of baseline values elicited renin release that was not completely blocked by either alpha adrenoceptor blockade with phentolamine or beta adrenoceptor blockade with propranolol. The renin release that persisted during propranolol administration was abolished by the alpha adrenoceptor antagonist, phentolamine, and by the prostaglandin synthetase inhibitor, indomethacin. The beta adrenergic component of renin release, elicited in the presence of phentolamine, was not blocked by indomethacin but abolished by propranolol. These data are consistent with the hypothesis that norepinephrine and epinephrine stimulate renin release by activation of both the renal beta and renal alpha adrenoceptors. The beta adrenoceptor-stimulated renin release appears to be direct and independent of the prostaglandin system, whereas the alpha adrenoceptor-stimulated renin release appears to be indirect and dependent on the generation of endogenous prostaglandins.
在麻醉的杂种犬中，评估了肾α和β肾上腺素能受体激活以及前列腺素合成在介导肾素释放以应对向肾内输注天然神经递质去甲肾上腺素和肾上腺素方面的作用。向肾内输注去甲肾上腺素和肾上腺素，剂量调整为使肾血流量减少至基线值的20%和50%，引发的肾素释放并未被酚妥拉明的α肾上腺素能受体阻断或普萘洛尔的β肾上腺素能受体阻断完全阻断。在普萘洛尔给药期间持续存在的肾素释放被α肾上腺素能受体拮抗剂酚妥拉明和前列腺素合成酶抑制剂吲哚美辛消除。在酚妥拉明存在的情况下引发的肾素释放的β肾上腺素能成分未被吲哚美辛阻断，但被普萘洛尔消除。这些数据与以下假设一致，即去甲肾上腺素和肾上腺素通过激活肾β和肾α肾上腺素能受体来刺激肾素释放。β肾上腺素能受体刺激的肾素释放似乎是直接的且独立于前列腺素系统，而α肾上腺素能受体刺激的肾素释放似乎是间接的且依赖于内源性前列腺素的生成。
