来自人类表皮的角蛋白前体蛋白。

Precursor keratin protein from human epidermis.

作者信息

Baynes J, Levine M, McLeod A, Wilkinson A

出版信息

Br J Dermatol. 1978 Feb;98(2):165-73. doi: 10.1111/j.1365-2133.1978.tb01618.x.

DOI:10.1111/j.1365-2133.1978.tb01618.x

Abstract

Prekeratin has been isolated from human epidermis using the method of Matoltsy for bovine nose epidermis. Analysis by sedimentation equilibrium indicates that human prekeratin is heterogeneous in solution. The molecular weight range is from about 200 X 10(3) to at least 2 X 10(6). Polyacrylamide gel electrophoresis shows three polypeptide chains of molecular weights 65,000 60,000 and 58,000. A lower than average ratio of polar/apolar amino acid residues suggests that hydrophobic interactions are important for stability.

摘要

已使用马托利茨基分离牛鼻表皮的方法从人表皮中分离出前角蛋白。沉降平衡分析表明，人源前角蛋白在溶液中具有异质性。分子量范围约为200×10³至至少2×10⁶。聚丙烯酰胺凝胶电泳显示出分子量分别为65000、60000和58000的三条多肽链。极性/非极性氨基酸残基的比例低于平均水平，这表明疏水相互作用对稳定性很重要。