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Phase II trial of aziridinylbenzoquinone (AZQ) in patients with refractory small cell carcinoma of the lung.

作者信息

Fuks J Z, Aisner J, Van Echo D A, Levitt M, Ihde D C, Carney D, Wiernik P H

出版信息

Am J Clin Oncol. 1983 Apr;6(2):171-3. doi: 10.1097/00000421-198304000-00005.

DOI:10.1097/00000421-198304000-00005
PMID:6299094
Abstract

Sixteen previously treated patients received AZQ in a phase II study to test therapeutic efficacy in refractory small cell lung cancer. The dose and schedule of AZQ was 20 mg/m2 day 1 and 8, with treatments repeated every 28 days. No objective responses were noted among 16 evaluable patients. Myelosuppression was the major toxicity. AZQ does not appear to have antitumor activity in patients with previously treated small cell carcinoma.

摘要

相似文献

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Phase II trial of aziridinylbenzoquinone (AZQ) in patients with refractory small cell carcinoma of the lung.
Am J Clin Oncol. 1983 Apr;6(2):171-3. doi: 10.1097/00000421-198304000-00005.
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引用本文的文献

1
Diaziquone (AZQ).
Invest New Drugs. 1983;1(1):71-84. doi: 10.1007/BF00180194.