Raj S G
Am J Obstet Gynecol. 1983 Mar 1;145(5):614-7. doi: 10.1016/0002-9378(83)91206-1.
A 29-year-old woman presented with hirsutism, obesity, oligomenorrhea, and infertility caused by oligoovulation and tubal occlusion. Partial 21-hydroxylase deficiency of the adrenal was suggested by an abnormal adrenocorticotropic hormone (ACTH) stimulation test. The patient subsequently developed bilateral tuboovarian abscesses and underwent abdominal hysterectomy and bilateral salpingo-oophorectomy. Thus, an opportunity was presented to study the adrenal endocrine disorder in the absence of ovaries and to investigate the effect of human chorionic gonadotropin (hCG) on the adrenals. There was no change in the adrenal response to ACTH stimulation after oophorectomy. hCG stimulation resulted in an increase in dehydroepiandrosterone sulfate and 17 beta-estradiol levels, suggesting that hCG had a stimulatory effect on the adrenal. The ovarian-adrenal relationship and effects of adrenal stimulation in the absence of ovaries are discussed.
一名29岁女性因排卵过少和输卵管阻塞出现多毛、肥胖、月经过少及不孕。促肾上腺皮质激素（ACTH）刺激试验异常提示肾上腺存在部分21-羟化酶缺乏。该患者随后发展为双侧输卵管卵巢脓肿，并接受了腹式子宫切除术和双侧输卵管卵巢切除术。因此，出现了一个在无卵巢情况下研究肾上腺内分泌紊乱以及探究人绒毛膜促性腺激素（hCG）对肾上腺影响的机会。卵巢切除术后，肾上腺对ACTH刺激的反应未发生变化。hCG刺激导致硫酸脱氢表雄酮和17β-雌二醇水平升高，提示hCG对肾上腺有刺激作用。本文讨论了卵巢-肾上腺关系以及无卵巢时肾上腺刺激的影响。
