Olson R O, Olson C, Easterday B C
Am J Vet Res. 1982 Dec;43(12):2250-2.
A 4th of 667 cattle examined at a Wisconsin abattoir had teat papillomas. Excised teat papillomas were sorted by gross morphologic characteristics into 3 groups: (i) atypical filiform, (ii) atypical flat, and (iii) typical fibropapilloma. Bovine papilloma virus capsid antigen was detected in thin-section slides of the 3 groups of teat papillomas by peroxidase-antiperoxidase assay. The bovine papilloma virus involved with the atypical papillomas could not be characterized by molecular hybridization, because enough pure virus could not be harvested. Homogenates of the 3 groups of teat papillomas were inoculated on 2 ponies and 4 calves. Typical fibropapillomas were produced on the 4 calves, and fibromas, on the 2 ponies. Atypical papillomas were produced only in 2 heifers.
在威斯康星州一家屠宰场检查的667头牛中，有1/4患有乳头瘤。切除的乳头瘤按大体形态特征分为3组：（i）非典型丝状，（ii）非典型扁平状，（iii）典型纤维乳头瘤。通过过氧化物酶-抗过氧化物酶测定法在3组乳头瘤的薄切片中检测到牛乳头瘤病毒衣壳抗原。由于无法收获足够的纯病毒，与非典型乳头瘤相关的牛乳头瘤病毒无法通过分子杂交进行鉴定。将3组乳头瘤的匀浆接种到2匹小马和4头小牛身上。4头小牛长出了典型纤维乳头瘤，2匹小马长出了纤维瘤。仅在2头小母牛身上长出了非典型乳头瘤。
