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小鼠脑中阿片受体的调节：弓状核损伤诱导受体上调及对阿片类药物超敏反应。

Regulation of opiate receptors in mouse brain: arcuate nuclear lesion induces receptor up-regulation and supersensitivity to opiates.

作者信息

Simantov R, Amir S

出版信息

Brain Res. 1983 Feb 28;262(1):168-71. doi: 10.1016/0006-8993(83)90483-3.

DOI:10.1016/0006-8993(83)90483-3
PMID:6299472
Abstract

Lesion of the hypothalamic arcuate nucleus of the mouse by neonatal application of monosodium glutamate (MSG) increased the binding of [3H]dihydromorphine to membranes prepared from the midbrain. A saturation curve of [3H]dihydromorphine binding indicated that MSG increased the number of the opiate receptors. The MSG-treated mice also exhibited an enhanced response to morphine and naltrexone regarding thermal pain sensitivity. The physiological implications of opiate receptors up-regulations upon arcuate nuclear lesion are discussed.

摘要

新生小鼠通过注射谷氨酸单钠（MSG）损伤下丘脑弓状核，可增加中脑制备膜上[3H]二氢吗啡的结合。[3H]二氢吗啡结合的饱和曲线表明，MSG增加了阿片受体的数量。MSG处理的小鼠在热痛敏感性方面对吗啡和纳曲酮也表现出增强的反应。本文讨论了弓状核损伤后阿片受体上调的生理意义。

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