Buckley N M, Brazeau P, Gootman P M
Fed Proc. 1983 Apr;42(6):1643-7.
The postnatal maturation of renal and femoral circulatory responses to catecholamines and to stimulation of their efferent sympathetic nerve supply has been examined in developing swine. Catecholamine dose-response experiments were carried out in intact animals under pentobarbital anesthesia. Effects of denervation and nerve stimulation were studied in intact animals and effects of neurotransmitter infusions were studied in preparations for in situ perfusion of kidney or hind limb. The renal circulation was found to be relatively sensitive to norepinephrine and under tonic neural vasoconstrictor influence at birth, and the femoral circulation was not. The femoral circulation was found to be relatively sensitive to isoproterenol at birth, whereas the renal circulation exhibited beta-adrenergic vasodilation by the end of the first postnatal week. The basic pressure-flow relationship in either circulation at any age was not altered by infusions of neurotransmitters into the arterial circuit after denervation of the perfused kidney or hind limb. Adrenergic innervation continued to mature rapidly in both circulations during the first postnatal week, as evidenced by the decreasing threshold and increasing magnitude of vasoconstrictor responses to electrical stimulation of the renal or lumbar nerves. A cholinergic component of the response to lumbar nerve stimulation became functional at 1 month after birth.
在发育中的猪身上，研究了肾脏和股循环对儿茶酚胺以及对其传出交感神经供应刺激的产后成熟情况。在戊巴比妥麻醉下，对完整动物进行了儿茶酚胺剂量反应实验。在完整动物中研究了去神经支配和神经刺激的作用，在肾脏或后肢原位灌注制剂中研究了神经递质输注的作用。发现肾循环对去甲肾上腺素相对敏感，在出生时受到紧张性神经血管收缩的影响，而股循环则不然。发现股循环在出生时对异丙肾上腺素相对敏感，而肾循环在出生后第一周结束时表现出β-肾上腺素能血管舒张。在对灌注的肾脏或后肢去神经后，向动脉回路中输注神经递质不会改变任何年龄时任一循环的基本压力-流量关系。产后第一周，两个循环中的肾上腺素能神经支配继续快速成熟，这表现为对肾神经或腰神经电刺激的血管收缩反应阈值降低、幅度增加。对腰神经刺激反应的胆碱能成分在出生后1个月开始发挥作用。
