Rasheed S, Gardner M B
Int J Cancer. 1983 Apr 15;31(4):491-6. doi: 10.1002/ijc.2910310415.
A gene named Akvr-1 segregates as a dominant allele in California wild mice (LC). Unlike Fv-1 and Fv-2 restriction alleles, the Akvr-1 confers resistance to replication of all ecotropic (N-, B-, and NB-tropic) murine leukemia viruses (MuLV-E) and prevents endogenous AKR virus-induced lymphoma/leukemia in F1 hybrids of AKR x LC. We have tested fibroblasts and hematopoietic cells from mice of defined Akvr-1 genotypes for in vitro susceptibility to various MuLV infections. Our results indicated a dominant in vitro resistance of exogenously MuLV-E infected cells carrying Akvr-1R allele although resistance was stronger in the homozygous cells than in the heterozygous cells. Moreover, resistance of cells to virus replication was not abrogated by high multiplicities of infection or by growth stimulation of hematopoietic cultures by various T- or B-cell-responsive mitogenic agents.
一个名为Akvr - 1的基因在加利福尼亚野生小鼠（LC）中作为显性等位基因分离。与Fv - 1和Fv - 2限制等位基因不同，Akvr - 1赋予对所有亲嗜性（N -、B -和NB -嗜性）鼠白血病病毒（MuLV - E）复制的抗性，并防止在AKR×LC的F1杂种中内源性AKR病毒诱导的淋巴瘤/白血病。我们已经测试了具有明确Akvr - 1基因型的小鼠的成纤维细胞和造血细胞对各种MuLV感染的体外易感性。我们的结果表明，携带Akvr - 1R等位基因的外源性MuLV - E感染细胞具有显性体外抗性，尽管纯合细胞中的抗性比杂合细胞中的更强。此外，细胞对病毒复制的抗性不会因高感染复数或各种T或B细胞反应性促有丝分裂剂对造血培养物的生长刺激而消除。
