小鼠逆转录病毒限制基因Fv-4和Akvr-1是单个基因座的等位基因。
Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus.
作者信息
O'Brien S J, Berman E J, Estes J D, Gardner M B
出版信息
J Virol. 1983 Sep;47(3):649-51. doi: 10.1128/JVI.47.3.649-651.1983.
Abstract
The two murine retroviral restriction genes, Fv-4 and Akvr-1, are very similar in their effects, distributions, ranges of action, and phenotypes. Akvr-1 has been shown to segregate independently in backcrosses with a variety of retroviral restriction loci, including Fv-1, Fv-2, Ril-1, and Ril-2. An allelism test cross of FRG (Fv-4R) X LCRR (Akvr-1R) hybrids mated to AKR mice failed to produce any viremic offspring. These results suggested that Akvr-1R and Fv-4R are alleles of a single locus, Fv-4, on mouse chromosome 12.
摘要
两种小鼠逆转录病毒限制基因Fv-4和Akvr-1在其作用、分布、作用范围和表型方面非常相似。已证明Akvr-1在与包括Fv-1、Fv-2、Ril-1和Ril-2在内的多种逆转录病毒限制位点的回交中独立分离。FRG（Fv-4R）×LCRR（Akvr-1R）杂种与AKR小鼠进行的等位性测交未能产生任何病毒血症后代。这些结果表明Akvr-1R和Fv-4R是小鼠12号染色体上单个位点Fv-4的等位基因。
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本文引用的文献
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Restricted expression of endogenous N-tropic XC-positive leukemia virus in hybrids between G and AKR mice: an effect of the Fv-4r gene.内源性N-嗜性XC阳性白血病病毒在G和AKR小鼠杂交后代中的限制性表达：Fv-4r基因的作用。
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Friend murine leukemia virus resistance in Japanese wild mice: possible allelism with Fv-4 in FRG mice.日本野生小鼠对Friend鼠白血病病毒的抗性：与FRG小鼠中Fv-4可能的等位性。
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