甲状腺素导致乳鼠胰腺中糜蛋白酶原过早减少。

Precocious decrease of chymotrypsinogen by thyroxine in the pancreas of suckling mice.

作者信息

Kumegawa M, Ikeda E, Takuma T

出版信息

Biochim Biophys Acta. 1978 Mar 1;539(2):261-4. doi: 10.1016/0304-4165(78)90013-2.

Abstract

Chymotrypsinogen activity in mouse pancreas gradually decreased from birth, reaching the adult level on day 20 after birth. In suckling mice the enzyme activity was decreased to 1/9 of the control value by injection of thyroxine. The activity was not affected by insulin, and was slightly increased, rather than decreased, by daily injection of hydrocortisone. The effect of thyroxine seemed to be direct, not due to modification of adrenal function.

摘要

小鼠胰腺中的胰凝乳蛋白酶原活性自出生起逐渐下降，在出生后第20天达到成年水平。在乳鼠中，通过注射甲状腺素，该酶活性降至对照值的1/9。胰岛素对该活性无影响，而每日注射氢化可的松会使其略有增加而非降低。甲状腺素的作用似乎是直接的，并非由于肾上腺功能的改变。