Varnier O E, Repetto C M, Raffanti S P, Alama A, Levy J A
J Gen Virol. 1983 Feb;64 (Pt 2):425-8. doi: 10.1099/0022-1317-64-2-425.
By co-cultivation procedures, infectious xenotropic type C viruses have been recovered from kidney cells of several strains of mice. They have host-range patterns which place them into separate subgroups. In cells cultivated from one NZB kidney, two biologically different xenotropic type C retroviruses were found. One, X-NZB/K-1, infects and replicates well in human and mink fibroblast cells but does not induce foci in mink S + L - cells with good efficiency. The other, X-NZB/K-2, infects and replicates well in mink but not human fibroblast cells, and induces foci readily in mink S + L - cells. Cross-infection studies indicate that these viruses, classified as xenotropic by host range and envelope properties, are genetically stable.
通过共培养程序，已从数种品系小鼠的肾细胞中分离出具有感染性的嗜异性C型病毒。它们具有宿主范围模式，可将它们分为不同的亚组。在从一只新西兰黑鼠（NZB）肾脏培养的细胞中，发现了两种生物学特性不同的嗜异性C型逆转录病毒。一种是X-NZB/K-1，能在人及貂成纤维细胞中感染并良好复制，但不能高效地在貂S+L-细胞中诱导病灶形成。另一种是X-NZB/K-2，能在貂成纤维细胞中感染并良好复制，但不能在人成纤维细胞中感染，且能轻易地在貂S+L-细胞中诱导病灶形成。交叉感染研究表明，这些根据宿主范围和包膜特性归类为嗜异性的病毒在基因上是稳定的。
