Tritsch G L, Niswander P W
Life Sci. 1983 Mar 21;32(12):1359-62. doi: 10.1016/0024-3205(83)90811-1.
Metabolic flux through the purine salvage pathway appears to modulate superoxide secretion by elicited macrophages. Exogenous adenosine, the first substrate of this pathway, stimulates superoxide secretion, and Allopurinol, a specific inhibitor of xanthine oxidase, inhibits superoxide secretion. The effects of these agents are additive since it was possible for each to neutralize the effects of the other when given in combination. In these experiments, the purine salvage pathway was responsible for over ten times the superoxide production attributable to the NADPH oxidase system.
通过嘌呤补救途径的代谢通量似乎可调节巨噬细胞诱导产生的超氧化物分泌。外源性腺苷作为该途径的首个底物，可刺激超氧化物分泌，而黄嘌呤氧化酶的特异性抑制剂别嘌呤醇则可抑制超氧化物分泌。这些药物的作用是相加的，因为当联合使用时，每种药物都能抵消另一种药物的作用。在这些实验中，嘌呤补救途径产生的超氧化物量是NADPH氧化酶系统的十倍以上。
