Stanford C, Nutt D J, Cowen P J
Neuroscience. 1983 Jan;8(1):161-4. doi: 10.1016/0306-4522(83)90035-0.
The effects of ten once-daily injections of desmethylimipramine (10 mg/kg i.p.) on alpha 2- and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus and hypothalamus. [3H]clonidine and [3H]dihydroalprenolol were used as ligands for alpha 2- and beta-adrenoceptors, respectively. Twenty-four hours after the last injection, the density of beta-adrenoceptors was reduced in all regions studied. In contrast, there was no change in alpha 2-adrenoceptor binding in the cortex, while increased binding was found in the hypothalamus. The effects of desmethylimipramine are discussed in relation to those of other antidepressant treatments.
研究了每日一次注射十次去甲丙咪嗪（10毫克/千克腹腔注射）对大鼠皮质、海马和下丘脑α₂-和β-肾上腺素能受体结合的影响。[³H]可乐定和[³H]二氢心得静分别用作α₂-和β-肾上腺素能受体的配体。最后一次注射后24小时，在所研究的所有区域中β-肾上腺素能受体的密度均降低。相比之下，皮质中的α₂-肾上腺素能受体结合没有变化，而下丘脑中的结合增加。讨论了去甲丙咪嗪与其他抗抑郁治疗的作用关系。
